Linking Activators and Basals in Transcription

STATs: Signal Transducers and Activators of Transcription

further duplicated. In recent evolution, the Stat5 gene Signal transducers and activators of transcription further duplicated. Since the Drosophila gene appears (STATs) were first identified as a unique family of DNAto be most related to Stat5, the Stat3–Stat5a/Stat5b site binding proteins approximately four years ago. Since may represent the ancestral gene site. that time, the number of mammal...

Differential Roles for Signal Transducers and Activators of Transcription 5a and 5b in PRL Stimulation of ER and ER Transcription

Department of Physiology and Biophysics (J.F., C.T., G.G.), University of Illinois at Chicago, Chicago, Illinois 60612; Department of Physiology (K.P., M.B., O.-K.P.-S.), University of Kentucky, Lexington, Kentucky 40536; Department of Hemopoietic Factors (T.K.), University of Tokyo, Tokyo 108-8639, Japan; Departments of Medicine, Molecular and Cell Biology, and Immunology (L.-Y.Y.-L.), Baylor ...

Linking Core Promoter Classes to Circadian Transcription

Circadian rhythms in transcription are generated by rhythmic abundances and DNA binding activities of transcription factors. Propagation of rhythms to transcriptional initiation involves the core promoter, its chromatin state, and the basal transcription machinery. Here, I characterize core promoters and chromatin states of genes transcribed in a circadian manner in mouse liver and in Drosophil...

Linking Transcription Factor Expression with DNA Binding

Dysregulation of janus kinases and signal transducers and activators of transcription in cancer.

Despite their long recognised pivotal roles in immunological responses, Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) are now seen as important players in cancer development and progression. Indeed, mutations in the JAKs are often found in myeloproliferative disorders (MPDs) and leukaemia, and the constitutive phosphorylation of STATs is a common occurrence...